Plasma concentrations of the active neuroleptic drugs, zuclopenthixol and fluphenazine, were. Download leaflet view the patient leaflet in pdf format. Guidelines for the use of zuclopenthixol acetate injection. Plasma concentrations of the active neuroleptic drugs, zuclopenthixol and fluphenazine, were determined by high performance liquid. Clopenthixol was introduced in 1961, while zuclopenthixol was introduced in 1978.
Guidelines for the use of zuclopenthixol acetate draft 5final. Zuclopenthixol clopixol, clopixol acuphase, clopixol concentrate is a first generation antipsychotic you can find detailed information about this drug in the official patient information leaflet pil, including what its for, how to take it, possible side effects and safety information. It belongs to a group of medicines known as antipsychotics also called neuroleptics. This medication is a longacting form of zuclopenthixol that is used to treat a certain mentalmood problem chronic schizophrenia. Zuclopentixol this is an easy way to read this word zooclo. Files are available under licenses specified on their description page. Schizophrenia is a condition where a person loses clarity of thought and memory. Some of the pictures are from the change health picture bank, change, units 1920, unity business centre, 26 roundhay road, leeds, ls7 1ab. Search the australian register of therapeutic goods. Zuclopenthixol brand names cisordinol, clopixol and others, also known as zuclopentixol, is a medication used to treat schizophrenia and other psychoses. Guidelines for the use of zuclopenthixol acetate clopixol. Zuclopenthixol marketed as cisordinol, clopixol or acuphase is a typical antipsychotic neuroleptic drug of the thioxanthene group. The effects of zuclopenthixol on aggressive behavior in patients with intellectual disabilities have previously been investigated seda32, 112, and a secondary parameter analysis of the results of this study has been published 141 r.
Both esters of zuclopenthixol are dissolved in fractionated coconut oil and when injected i. When there is an advance directive for the use of zuclopenthixol acetate. Zuclopenthixol is predicted to decrease the effects of amantadine. All structured data from the file and property namespaces is available under the creative commons cc0 license. Zuclopenthixol is a mediumacting drug and has an onset of action in 1 hour and a duration of action of about 3 to 4 days. It is the cis isomer of clopenthixol sordinol, ciatyl. Some of the brands for zuclopenthixol might be better known than zuclopenthixol itself. Zuclopenthixol dominates over metabolites in brain and other tissues. Fowlers zoo and wild animal medicine, volume 8, 2015.
Zuclopenthixol can sometimes be called a different name like clopixol. Zuclopenthixol zuclopenthixol is a medication that will help if you have schizophrenia or other psychosis. This drug is a medicine for this condition as well as some other problems and is a well known antipsychotic drug. Christof schaefer, in drugs during pregnancy and lactation second edition, 2007. As for other neuroleptics, zuclopenthixol is distributed with highest. If the pharmacy thats willing to deliver medicines to your home doesnt have zuclopenthixol in stock, you can ask for one of the branded alternatives for zuclopenthixol. What zuclopenthixol decanoate looks like and contents of the pack zuclopenthixol decanoate is a clear, yellowish oil in transparent glass ampoules with a red scored dot. Reduction in selfharming behaviour after zuclopenthixol decanoate article pdf available in progress in neurology and psychiatry 184 july 2014 with 225 reads how we measure reads. Zuclopentixol this is an easy way to read this word zoo.
Zuclopenthixol decanoate for schizophrenia and other serious mental illnesses. Initially 2030 mg daily in divided doses, increased if necessary up to 150 mg daily. The elimination of zuclopenthixol after single oral dose administration has been shown to be dependent on cyp2d6 activity dahl et al. Zuclopenthixol acetate and zuclopenthixol decanoate are longacting forms of zuclopenthixol that have been made more lipophilic by esterification with acetic and decanoic acid, respectively.
It is the cisisomer of clopenthixol sordinol, ciatyl. Zuclopenthixol clopixol, clopixol acuphase, clopixol concentrate is a first generation antipsychotic you can find detailed information about this drug in the official patient information leaflet pil, including what its for, how to take it. Severe laryngeal dystonia in a patient receiving zuclopenthixol acuphase and fluoxetine. Zuclopenthixol drug information indications, dosage, side. In an attempt to hasten the antipsychotic effect of other prescribed antipsychotics. Dose should be v to lowest dose needed to control symptoms usual range 2040 mgday. A limited number of patients switched from a typical to an atypical antipsychotic or were given exceptionally a typical antipsychotic during hospitalization. Manufacturer and product licence holder manufactured by h. Tablets zuclopenthixol 2mg tablets tablets zuclopenthixol 10mg tablets zuclopenthixol dihydrochloride this product is available using any of the above names but will be referred to as clopixol tablets throughout this leaflet.
Clopixol tablets 2, 10 and 25mg patient information leaflet. Zuclopenthixol was associated with no greater risk of being unchanged or worse compared with risperidone n 98, 1 rct, rr 1. Seventeen outpatients were treated with depot neuroleptics, zuclopenthixol decanoate in viscoleo or fluphenazine decanoate in sesame oil, with dosage intervals of 3 weeks. A dose of 200 mg2 weeks or 400 mg4 weeks zuclopenthixol decanoate is expected to be equivalent to a daily dose of 25 mg zuclopenthixol as the dihydrochloride. Zuclopenthixol can sometimes be called a different names like clopixol and zuclopenthixol decanoate. Zuclopenthixol interactions bnf content published by nice. Most manufacturers advise avoiding the use of two or more drugs that are associated with qt prolongation. The other ingredients are potato starch, lactose, microcrystalline cellulose, copolyvidone, glycerol, talc, hydrogenated castor oil, magnesium stearate, methylhydroxypropyl cellulose, macrogol, titanium dioxide e171 and the red. Both zuclopenthixol and amifampridine prolong the qt interval. If you have an allergy to zuclopenthixol or any other part of this drug. Zuclopenthixol cisordinol generic is a neuroleptic or antipsychotic compound, prescribed for schizophrenia and other mental health disorders. Major brands of zuclopenthixol are cisordinol, acuphase, and clopixol. Zuclopenthixol is a drug that is aimed at treating and curing the disease schizophrenia.
The medication is blocking many receptors in the brain, including dopamine receptors, which controls behavior and mood. When there is a documented history that the patient experienced a good clinical effect and good tolerability. During the 4th, 6th, and 8th dosage interval blood samples were drawn in oxalated tubes. Each tablet contains 2 mg, 10 mg or 25 mg of zuclopenthixol. Average levels of zuclopenthixol in dogs injected zuclopenthixbl dihydrochloride in aqueous solution n 4 l, zuclopenthixol acetate in oil n 4 2 and zuclopenthixol decanoate. Zuclopenthixol definition of zuclopenthixol by medical. People allocated zuclopenthixol were prescribed antiparkinsonian medication more frequently compared with those treated with risperidone n 98, 1 rct, rr 1. Zuclopentixol injection this is an easy way to read this word. An intramuscular injection takes 36 hours to produce a maximum serum concentration. Zuclopenthixol as dihydrochloride read all of this leaflet carefully before you start taking this medicine because it contains important information for you. Zuclopenthixol decanoate as a very lipophilic substance is slowly released from the oil depot. Clopixol injection contains the active substance zuclopenthixol. Zuclopenthixol drug information indications, dosage.
Zuclopenthixol is a medication that will help if you have schizophrenia or other psychosis. Zuclopenthixol memorial sloan kettering cancer center. In nursing mothers zuclopenthixol is excreted in small amounts with the breast milk. Guidelines for the use of zuclopenthixol acetate clopixol acuphase injection introduction in the past, acuphase has often been too widely and possibly inappropriately used, sometimes without full regard being given to the fact that it is a potentially hazardous and toxic preparation with very little published information to support its use. This drug is a medicine for this condition as well as some other problems. The concentration falls by approximately 60% over 3 days so the injection can be repeated after 2 or 3 days if needed. Zuclopenthixol injection for behaviour problems this is an unofficial information leaflet. Zuclopenthixol is a thioxanthenebased neuroleptic with therapeutic actions similar to the phenothiazine antipsychotics.
Clopixol tablets 2, 10 and 25mg patient information. It is an antagonist at d1 and d2 dopamine receptors. This page was last edited on 10 december 2015, at 00. Zuclopenthixol for behaviour problems this is an unofficial information leaflet. Zuclopenthixol is excreted mainly with faeces, but also to some degree about 10 % with the urine. Reduction in selfharming behaviour after zuclopenthixol. Zuclopenthixol uses, side effects, substitutes, composition. This leaflet was produced in october 2006 what do i need to know about zuclopentixol. This formulation of zuclopenthixol is indicated for the treatment of acute psychoses, mania or exacerbations of chronic psychoses. Information about zuclopenthixol decanoate injection.
Improvement of zuclopenthixol decanoate induced tardive dyskinesia after switching to paliperidone palmitate. A typical antipsychotic neuroleptic drug of the thioxanthene group. Zuclopentixol injection this is an easy way to read this. These medicines act on nerve pathways in specific areas of the brain and help to correct certain chemical imbalances in the brain that are causing the symptoms of your illness. Find information on zuclopenthixol in daviss drug guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. It is classed, pharmacologically, as a typical antipsychotic.
It mainly acts by antagonism of d 1 and d 2 dopamine receptors, though it also has some antihistamine activity. Clopixol injection patient information leaflet pil emc. Po adults acute psychoses 1050 mgday in 23 divided doses initially. Comparative study of the pharmacokinetics of zuclopenthixol. It is produced and marketed by lundbeck pharmaceutical company. We have a leaflet which tells you what off label means. Zuclopenthixol, also known as zuclopentixol or zuclopenthixolum, is an antipsychotic agent. Zuclopenthixolcisordinol generic is a neuroleptic or antipsychotic compound, prescribed for schizophrenia and other mental health disorders.
Among eight women who received 450mg zuclopenthixol daily, an average mp ratio of 0. A very bad and sometimes deadly health problem called neuroleptic malignant. Zuclopenthixol can be used off label to help people with we have a leaflet which tells you what off label means. Jan 25, 2017 the active substance is zuclopenthixol dihydrochloride. Zuclopenthixol decanoate is available in a carton of 10 ampoules.
Zuclopenthixol is a generic medicine name and there are several brands available for it. Zuclopenthixol decanoate is usually used in patients who have benefited from regular doses of shortacting forms of zuclopenthixol and who may benefit from longterm maintenance treatment with less frequent dosing. Tell your doctor about the allergy and what signs you had. Maximum concentration was obtained after 4 days in the dogs, then the curve declined very slowly, zuclopenthixol being measurable until 28 days after injection.
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